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KMID : 0363320080290020348
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Journal of Korean Oriental Internal Medicine
2008 Volume.29 No. 2 p.348 ~ p.358
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Experimental Studies on the Anti-diarrhea Effects of Jisa-tang
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Ryu Ihn-Soo
Kim Jin-Sung
Ryu Bong-Ha
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Abstract
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Objective : The aim of this experimental study was to investigate the anti-diarrhea effects of Jisa-tang using mice and guinea pigs.
Methods : We feed Jisa-tang to mice and guinea pigs to investigate its effects for anti-diarrhea action. We observed its actions on gastrointestinal smooth muscles, on the transportability of small and large intestines, on diarrhea induced by castor oil and magnesium sulfate, and on enteropooling by castor oil and prostaglandin .
Results : 1. Jisa-tang showed alleviation, depending on the density, only on the contraction of mice’s gastrointestinal smooth muscles induced by histamine. 2. The transportability of the small intestine was not significantly constrained by Jisa-tang. However, the enhancement of pyridostigmine-induced transportability of he small intestine was significantly constrained in the group administered 900mg/kg of Jisa-tang (p<0.05). 3. The transportability of large intestine was significantly constrained in the group administered 1,800mg/kg of Jisa-tang. 4. Jisa-tang showed significant anti-diarrhea effects on diarrhea induced by castor oil and by in the group administered 1,800mg/kg of Jisa-tang. 5. Significant reduction of effects of enteropooling induced by caster oil and by prostaglandin were observed only in the group administered 1,800mg/kg of Jisa-tang.
Conclusions : We conclude that Jisa-tang has advantageous effects on drug-induced diarrhea and will contribute to the development of diarrhea treatment through further related studies.
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KEYWORD
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Jisa-tang, Diarrhea, Herb, Oriental Medicine
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